Drug interactions
Ibuprofen + Miconazole vaginal
Severity: Minor
Ibuprofen and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic miconazole inhibits CYP2C9 and can raise levels of its substrates, but vaginal absorption is low. A meaningful effect on ibuprofen is unlikely with typical vaginal use.
What this interaction means in plain words
Ibuprofen and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Miconazole inhibits CYP2C9, though systemic exposure from vaginal use is low.
What to do
No action is generally needed; be more watchful for NSAID adverse effects if prolonged or repeated vaginal courses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Miconazole vaginal?
MediHelp rates the interaction as minor. Ibuprofen and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic miconazole inhibits CYP2C9 and can raise levels of its substrates, but vaginal absorption is low. A meaningful effect on ibuprofen is unlikely with typical vaginal use.
How serious is the interaction between Ibuprofen and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; be more watchful for NSAID adverse effects if prolonged or repeated vaginal courses are used.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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