Drug interactions
Ibuprofen + Mipomersen
Severity: Moderate
Ibuprofen and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause elevated transaminases and hepatic fat accumulation. Ibuprofen can rarely cause liver enzyme elevations, so concurrent use may add to liver injury risk.
What this interaction means in plain words
Ibuprofen and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes according to the mipomersen monitoring schedule and more closely if regular NSAID use is needed. Stop the offending drug if significant transaminase elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Mipomersen?
MediHelp rates the interaction as moderate. Ibuprofen and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause elevated transaminases and hepatic fat accumulation. Ibuprofen can rarely cause liver enzyme elevations, so concurrent use may add to liver injury risk.
How serious is the interaction between Ibuprofen and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes according to the mipomersen monitoring schedule and more closely if regular NSAID use is needed. Stop the offending drug if significant transaminase elevations occur.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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