Drug interactions
Ibuprofen + Nefazodone
Severity: Moderate
Ibuprofen and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity that can impair platelet function. With an NSAID such as ibuprofen, the risk of bleeding, especially GI, may be raised, though nefazodone has weaker serotonin reuptake inhibition than SSRIs.
What this interaction means in plain words
Ibuprofen and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet aggregation together with NSAID-related gastric mucosal injury.
What to do
Watch for signs of GI bleeding and consider gastroprotection in older patients or those with ulcer history. Use paracetamol (acetaminophen) where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Nefazodone?
MediHelp rates the interaction as moderate. Ibuprofen and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity that can impair platelet function. With an NSAID such as ibuprofen, the risk of bleeding, especially GI, may be raised, though nefazodone has weaker serotonin reuptake inhibition than SSRIs.
How serious is the interaction between Ibuprofen and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of GI bleeding and consider gastroprotection in older patients or those with ulcer history. Use paracetamol (acetaminophen) where suitable.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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