Drug interactions
Ibuprofen + Neomycin po
Severity: Minor
Ibuprofen and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed in adults, so systemic exposure is minimal. The interaction is described mainly in preterm infants receiving ibuprofen, where reduced renal clearance raises aminoglycoside levels.
What this interaction means in plain words
Ibuprofen and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID reduction of renal blood flow may decrease aminoglycoside clearance, relevant mainly when neomycin is absorbed.
What to do
No action is needed in most adults; in neonates or patients with renal impairment or inflamed gut, monitor renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Neomycin po?
MediHelp rates the interaction as minor. Ibuprofen and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed in adults, so systemic exposure is minimal. The interaction is described mainly in preterm infants receiving ibuprofen, where reduced renal clearance raises aminoglycoside levels.
How serious is the interaction between Ibuprofen and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed in most adults; in neonates or patients with renal impairment or inflamed gut, monitor renal function.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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