Drug interactions
Ibuprofen + Olmesartan
Severity: Moderate
Ibuprofen and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the antihypertensive effect of olmesartan and, together, they can impair renal function, especially in elderly, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
What this interaction means in plain words
Ibuprofen and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Olmesartan belongs to Cardiovascular.
Why it happens
NSAIDs constrict the afferent arteriole by blocking prostaglandins while ARBs dilate the efferent arteriole, reducing glomerular filtration pressure, and NSAIDs also cause sodium retention.
What to do
Ensure adequate hydration and monitor serum creatinine, potassium and blood pressure, particularly at the start of therapy. Avoid regular NSAID use in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ibuprofen and Olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Ibuprofen with Olmesartan?
MediHelp rates the interaction as moderate. Ibuprofen and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce the antihypertensive effect of olmesartan and, together, they can impair renal function, especially in elderly, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
How serious is the interaction between Ibuprofen and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine, potassium and blood pressure, particularly at the start of therapy. Avoid regular NSAID use in high-risk patients.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
