Drug interactions
Ibuprofen + Phenindione
Severity: Major
Ibuprofen and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist, and ibuprofen impairs platelet function and can cause GI ulceration. Together they substantially raise the risk of serious bleeding.
What this interaction means in plain words
Ibuprofen and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment from vitamin K antagonism and NSAID platelet inhibition with mucosal injury.
What to do
Avoid ibuprofen and use paracetamol where possible; if unavoidable, monitor INR and bleeding signs and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Phenindione?
MediHelp rates the interaction as major. Ibuprofen and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist, and ibuprofen impairs platelet function and can cause GI ulceration. Together they substantially raise the risk of serious bleeding.
How serious is the interaction between Ibuprofen and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ibuprofen and use paracetamol where possible; if unavoidable, monitor INR and bleeding signs and consider gastroprotection.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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