Drug interactions
Ibuprofen + Piperacillin-tazobactam
Severity: Minor
Ibuprofen and Piperacillin-tazobactam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic acids secreted by renal tubular transporters, so piperacillin may slightly slow ibuprofen elimination. Separately, NSAIDs combined with piperacillin-tazobactam may add to renal risk in vulnerable patients.
What this interaction means in plain words
Ibuprofen and Piperacillin-tazobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Piperacillin-tazobactam belongs to Anti Bacterial.
Why it happens
Competition for renal tubular secretion via organic anion transporters.
What to do
No dose change is usually needed. Monitor renal function in patients who are dehydrated, elderly or have kidney disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Piperacillin-tazobactam
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Piperacillin-tazobactam?
MediHelp rates the interaction as minor. Ibuprofen and Piperacillin-tazobactam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic acids secreted by renal tubular transporters, so piperacillin may slightly slow ibuprofen elimination. Separately, NSAIDs combined with piperacillin-tazobactam may add to renal risk in vulnerable patients.
How serious is the interaction between Ibuprofen and Piperacillin-tazobactam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor renal function in patients who are dehydrated, elderly or have kidney disease.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
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