Drug interactions
Ibuprofen + Prazosin
Severity: Minor
Ibuprofen and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce the blood pressure lowering effect of alpha-blockers such as prazosin, though the effect is generally modest.
What this interaction means in plain words
Ibuprofen and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ibuprofen belongs to Musculoskeletal; Prazosin belongs to Genitourinary.
Why it happens
Prostaglandin inhibition causes sodium and water retention and reduced vasodilation.
What to do
Check blood pressure when ibuprofen is used regularly and adjust antihypertensive dosing if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Ibuprofen with Prazosin?
MediHelp rates the interaction as minor. Ibuprofen and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may reduce the blood pressure lowering effect of alpha-blockers such as prazosin, though the effect is generally modest.
How serious is the interaction between Ibuprofen and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure when ibuprofen is used regularly and adjust antihypertensive dosing if control worsens.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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