Drug interactions
Ibuprofen + Reteplase
Severity: Major
Ibuprofen and Reteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic that substantially raises bleeding risk. Ibuprofen inhibits platelet function and can injure the gastric mucosa, adding to the likelihood of serious hemorrhage.
What this interaction means in plain words
Ibuprofen and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment: fibrinolysis from reteplase plus NSAID-mediated platelet inhibition and mucosal injury.
What to do
Avoid giving NSAIDs around thrombolytic therapy unless essential. Monitor closely for bleeding, including at puncture sites and in the gastrointestinal tract.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Reteplase?
MediHelp rates the interaction as major. Ibuprofen and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase is a thrombolytic that substantially raises bleeding risk. Ibuprofen inhibits platelet function and can injure the gastric mucosa, adding to the likelihood of serious hemorrhage.
How serious is the interaction between Ibuprofen and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving NSAIDs around thrombolytic therapy unless essential. Monitor closely for bleeding, including at puncture sites and in the gastrointestinal tract.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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