Drug interactions
Ibuprofen + Sacubitril / valsartan
Severity: Major
Ibuprofen and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can impair renal function in patients taking sacubitril/valsartan, particularly in older adults or those who are volume depleted. They may also blunt the antihypertensive effect and raise potassium.
What this interaction means in plain words
Ibuprofen and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAIDs inhibit prostaglandin-mediated afferent arteriolar dilation while angiotensin receptor blockade dilates the efferent arteriole, reducing glomerular filtration; NSAIDs also promote sodium retention and hyperkalemia.
What to do
Avoid regular NSAID use where possible. If needed, monitor renal function, potassium and blood pressure, and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Sacubitril / valsartan?
MediHelp rates the interaction as major. Ibuprofen and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can impair renal function in patients taking sacubitril/valsartan, particularly in older adults or those who are volume depleted. They may also blunt the antihypertensive effect and raise potassium.
How serious is the interaction between Ibuprofen and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible. If needed, monitor renal function, potassium and blood pressure, and ensure adequate hydration.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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