Drug interactions
Ibuprofen + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Ibuprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs reduce renal perfusion. Together they raise the risk of acute kidney injury.
What this interaction means in plain words
Ibuprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion from catharsis combined with NSAID inhibition of renal prostaglandins reduces renal blood flow.
What to do
Avoid ibuprofen around bowel preparation, especially in older adults or those with kidney disease, and maintain hydration. Check renal function and electrolytes if the combination is necessary.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Ibuprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and NSAIDs reduce renal perfusion. Together they raise the risk of acute kidney injury.
How serious is the interaction between Ibuprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ibuprofen around bowel preparation, especially in older adults or those with kidney disease, and maintain hydration. Check renal function and electrolytes if the combination is necessary.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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