Drug interactions
Ibuprofen + Sulfamethoxazole
Severity: Minor
Ibuprofen and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9 and could raise ibuprofen concentrations somewhat. Clinically important effects are unlikely, though NSAIDs and sulfonamides can each affect the kidney.
What this interaction means in plain words
Ibuprofen and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sulfamethoxazole inhibits CYP2C9, reducing ibuprofen metabolism.
What to do
No routine adjustment is needed; watch for gastrointestinal upset and check renal function if the combination is used in patients with kidney risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Sulfamethoxazole?
MediHelp rates the interaction as minor. Ibuprofen and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole inhibits CYP2C9 and could raise ibuprofen concentrations somewhat. Clinically important effects are unlikely, though NSAIDs and sulfonamides can each affect the kidney.
How serious is the interaction between Ibuprofen and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for gastrointestinal upset and check renal function if the combination is used in patients with kidney risk factors.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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