Drug interactions
Ibuprofen + Telmisartan-amlodipine
Severity: Moderate
Ibuprofen and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the blood pressure lowering effect of telmisartan and, together with an ARB, may impair renal function and raise potassium, particularly in older or dehydrated patients.
What this interaction means in plain words
Ibuprofen and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces glomerular perfusion and sodium excretion, opposing ARB effects.
What to do
Use the lowest ibuprofen dose for the shortest time and monitor blood pressure, creatinine and potassium. Choose paracetamol where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Ibuprofen and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can reduce the blood pressure lowering effect of telmisartan and, together with an ARB, may impair renal function and raise potassium, particularly in older or dehydrated patients.
How serious is the interaction between Ibuprofen and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest ibuprofen dose for the shortest time and monitor blood pressure, creatinine and potassium. Choose paracetamol where suitable.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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