Drug interactions
Ibuprofen + Tenofovir df
Severity: Moderate
Ibuprofen and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is eliminated by the kidney through filtration and tubular secretion, and NSAIDs can reduce renal perfusion. Regular or high-dose ibuprofen with tenofovir DF has been associated with an increased risk of acute kidney injury and tenofovir-related tubular toxicity.
What this interaction means in plain words
Ibuprofen and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction of renal prostaglandin-mediated perfusion combined with tenofovir proximal tubular toxicity produces additive nephrotoxicity and may raise tenofovir exposure.
What to do
Prefer paracetamol or non-NSAID analgesia where possible, and avoid prolonged or high-dose NSAID use. If an NSAID is needed, monitor serum creatinine, phosphate and urinalysis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Tenofovir df?
MediHelp rates the interaction as moderate. Ibuprofen and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is eliminated by the kidney through filtration and tubular secretion, and NSAIDs can reduce renal perfusion. Regular or high-dose ibuprofen with tenofovir DF has been associated with an increased risk of acute kidney injury and tenofovir-related tubular toxicity.
How serious is the interaction between Ibuprofen and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or non-NSAID analgesia where possible, and avoid prolonged or high-dose NSAID use. If an NSAID is needed, monitor serum creatinine, phosphate and urinalysis.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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