Drug interactions
Ibuprofen + Tenofovir disoproxil
Severity: Moderate
Ibuprofen and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by glomerular filtration and tubular secretion and can itself cause kidney injury. NSAIDs reduce renal prostaglandin-mediated perfusion, and reports describe acute kidney injury when NSAIDs are used with tenofovir, particularly at high or repeated doses.
What this interaction means in plain words
Ibuprofen and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with NSAID-induced reduction in renal perfusion that may raise tenofovir exposure.
What to do
Use the lowest effective NSAID dose for the shortest time, or choose paracetamol where suitable. Monitor serum creatinine and phosphate, especially in those with renal risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Ibuprofen and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by glomerular filtration and tubular secretion and can itself cause kidney injury. NSAIDs reduce renal prostaglandin-mediated perfusion, and reports describe acute kidney injury when NSAIDs are used with tenofovir, particularly at high or repeated doses.
How serious is the interaction between Ibuprofen and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, or choose paracetamol where suitable. Monitor serum creatinine and phosphate, especially in those with renal risk factors.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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