Drug interactions
Ibuprofen + Ticarcillin
Severity: Moderate
Ibuprofen and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin can impair platelet function and cause bleeding at high doses, and ibuprofen also inhibits platelets. Together the bleeding tendency may be increased.
What this interaction means in plain words
Ibuprofen and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive platelet dysfunction: ticarcillin interferes with platelet aggregation while ibuprofen inhibits COX-1.
What to do
Monitor for bleeding signs, and check coagulation tests and renal function in high-dose therapy or renal impairment. Prefer paracetamol for analgesia where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Ticarcillin?
MediHelp rates the interaction as moderate. Ibuprofen and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin can impair platelet function and cause bleeding at high doses, and ibuprofen also inhibits platelets. Together the bleeding tendency may be increased.
How serious is the interaction between Ibuprofen and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs, and check coagulation tests and renal function in high-dose therapy or renal impairment. Prefer paracetamol for analgesia where suitable.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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