Drug interactions
Ibuprofen + Tobramycin inhaled
Severity: Moderate
Ibuprofen and Tobramycin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled tobramycin has low but measurable systemic absorption, especially with renal impairment, and aminoglycosides are nephrotoxic and ototoxic. NSAIDs such as ibuprofen can reduce renal function and may increase the risk of kidney injury and aminoglycoside accumulation.
What this interaction means in plain words
Ibuprofen and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with NSAID-related reduction in renal blood flow potentially reducing aminoglycoside clearance.
What to do
Monitor serum creatinine and, if systemic exposure is a concern, tobramycin serum levels. Consider hearing assessment in prolonged use and minimize the NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Tobramycin inhaled?
MediHelp rates the interaction as moderate. Ibuprofen and Tobramycin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled tobramycin has low but measurable systemic absorption, especially with renal impairment, and aminoglycosides are nephrotoxic and ototoxic. NSAIDs such as ibuprofen can reduce renal function and may increase the risk of kidney injury and aminoglycoside accumulation.
How serious is the interaction between Ibuprofen and Tobramycin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and, if systemic exposure is a concern, tobramycin serum levels. Consider hearing assessment in prolonged use and minimize the NSAID dose and duration.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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