Drug interactions
Ibuprofen / famotidine + Ledipasvir-sofosbuvir
Severity: Moderate
Ibuprofen / famotidine and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which can reduce ledipasvir absorption. The effect is limited at standard doses and is managed by dose and timing limits.
What this interaction means in plain words
Ibuprofen / famotidine and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Higher gastric pH from H2-receptor blockade reduces ledipasvir solubility.
What to do
Give famotidine at the same time as or 12 hours apart from ledipasvir/sofosbuvir, not exceeding 40 mg twice daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Frequently asked questions
Can I take Ibuprofen / famotidine with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Ibuprofen / famotidine and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine raises gastric pH, which can reduce ledipasvir absorption. The effect is limited at standard doses and is managed by dose and timing limits.
How serious is the interaction between Ibuprofen / famotidine and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give famotidine at the same time as or 12 hours apart from ledipasvir/sofosbuvir, not exceeding 40 mg twice daily.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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