Drug interactions
Ibuprofen / famotidine + Melphalan
Severity: Minor
Ibuprofen / famotidine and Melphalan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced oral melphalan absorption has been suggested with acid-reducing or NSAID co-medication, but the effect is not well established. Clinical significance is unclear.
What this interaction means in plain words
Ibuprofen / famotidine and Melphalan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible altered gastrointestinal absorption of oral melphalan; mechanism not firmly established.
What to do
No routine change needed; monitor response and blood counts during oral melphalan therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melphalan
- Adenovirus types 4 and 7 live + Melphalan Contraindicated
- Bcg vaccine live + Melphalan Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Melphalan Contraindicated
- Measles mumps and rubella vaccine live + Melphalan Contraindicated
- Measles mumps and rubella vaccine + Melphalan Contraindicated
- Measles mumps rubella and varicella vaccine live + Melphalan Contraindicated
Frequently asked questions
Can I take Ibuprofen / famotidine with Melphalan?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Melphalan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced oral melphalan absorption has been suggested with acid-reducing or NSAID co-medication, but the effect is not well established. Clinical significance is unclear.
How serious is the interaction between Ibuprofen / famotidine and Melphalan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change needed; monitor response and blood counts during oral melphalan therapy.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
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