Drug interactions
Ibuprofen / famotidine + Metformin-repaglinide
Severity: Minor
Ibuprofen / famotidine and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine is a renally secreted cationic drug and may modestly reduce metformin tubular secretion, slightly raising metformin levels. NSAIDs such as ibuprofen can also impair renal function, which may increase metformin accumulation.
What this interaction means in plain words
Ibuprofen / famotidine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular cation transport (OCT2/MATE) and possible NSAID-related reduction in renal function.
What to do
Monitor renal function in patients on long-term NSAIDs and metformin, and avoid combining if renal function is impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Ibuprofen / famotidine with Metformin-repaglinide?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine is a renally secreted cationic drug and may modestly reduce metformin tubular secretion, slightly raising metformin levels. NSAIDs such as ibuprofen can also impair renal function, which may increase metformin accumulation.
How serious is the interaction between Ibuprofen / famotidine and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients on long-term NSAIDs and metformin, and avoid combining if renal function is impaired.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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