Drug interactions
Ibuprofen / famotidine + Pazopanib
Severity: Moderate
Ibuprofen / famotidine and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption depends on acidic gastric pH, and the H2 antagonist famotidine can lower its exposure and possibly reduce efficacy. Ibuprofen itself does not meaningfully affect this.
What this interaction means in plain words
Ibuprofen / famotidine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Famotidine raises gastric pH, decreasing the solubility and absorption of pazopanib.
What to do
If acid suppression is needed, use a short-acting antacid separated from pazopanib by several hours, or give pazopanib at least 2 hours before and 10 hours after famotidine. Monitor response to pazopanib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Ibuprofen / famotidine with Pazopanib?
MediHelp rates the interaction as moderate. Ibuprofen / famotidine and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib absorption depends on acidic gastric pH, and the H2 antagonist famotidine can lower its exposure and possibly reduce efficacy. Ibuprofen itself does not meaningfully affect this.
How serious is the interaction between Ibuprofen / famotidine and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If acid suppression is needed, use a short-acting antacid separated from pazopanib by several hours, or give pazopanib at least 2 hours before and 10 hours after famotidine. Monitor response to pazopanib.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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