Drug interactions
Ibuprofen / famotidine + Sofosbuvir-velpatasvir
Severity: Moderate
Ibuprofen / famotidine and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which can lower velpatasvir absorption. At modest H2 blocker doses the effect is manageable with appropriate timing.
What this interaction means in plain words
Ibuprofen / famotidine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
H2 antagonist-induced increase in gastric pH reduces velpatasvir solubility.
What to do
Give famotidine simultaneously with or 12 hours apart from sofosbuvir/velpatasvir, with total dose not above famotidine 40 mg twice daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ibuprofen / famotidine and Sofosbuvir-velpatasvir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Frequently asked questions
Can I take Ibuprofen / famotidine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Ibuprofen / famotidine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine raises gastric pH, which can lower velpatasvir absorption. At modest H2 blocker doses the effect is manageable with appropriate timing.
How serious is the interaction between Ibuprofen / famotidine and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give famotidine simultaneously with or 12 hours apart from sofosbuvir/velpatasvir, with total dose not above famotidine 40 mg twice daily.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
