Drug interactions
Icosapent + Meclofenamic acid
Severity: Moderate
Icosapent and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icosapent ethyl may prolong bleeding time and meclofenamic acid impairs platelet function and can injure the gastric lining. Together the risk of bleeding may be modestly increased.
What this interaction means in plain words
Icosapent and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: omega-3 modification of platelet function plus NSAID COX-1 inhibition.
What to do
Monitor for bleeding signs periodically during combined use. Consider gastroprotection in patients at high GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Frequently asked questions
Can I take Icosapent with Meclofenamic acid?
MediHelp rates the interaction as moderate. Icosapent and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Icosapent ethyl may prolong bleeding time and meclofenamic acid impairs platelet function and can injure the gastric lining. Together the risk of bleeding may be modestly increased.
How serious is the interaction between Icosapent and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs periodically during combined use. Consider gastroprotection in patients at high GI risk.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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