Drug interactions
Idarubicin + Istradefylline
Severity: Moderate
Idarubicin and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses increases exposure to P-glycoprotein substrates and may raise idarubicin levels. This could increase myelosuppression and cardiotoxicity.
What this interaction means in plain words
Idarubicin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idarubicin belongs to Oncology; Istradefylline belongs to Central Nervous System.
Why it happens
P-gp inhibition by istradefylline reduces idarubicin efflux.
What to do
Monitor blood counts and cardiac function. Consider dose reduction of idarubicin if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Idarubicin with Istradefylline?
MediHelp rates the interaction as moderate. Idarubicin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Istradefylline at higher doses increases exposure to P-glycoprotein substrates and may raise idarubicin levels. This could increase myelosuppression and cardiotoxicity.
How serious is the interaction between Idarubicin and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function. Consider dose reduction of idarubicin if toxicity occurs.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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