Drug interactions
Idarubicin + Sotorasib
Severity: Moderate
Idarubicin and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib has been shown to inhibit P-glycoprotein, so higher idarubicin exposure is plausible rather than lower. The clinical consequence is poorly characterised and could include more myelosuppression or cardiotoxicity.
What this interaction means in plain words
Idarubicin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idarubicin belongs to Oncology; Sotorasib belongs to Oncology.
Why it happens
Sotorasib inhibits P-gp, which may reduce efflux of idarubicin; the clinical effect has not been well studied.
What to do
Monitor blood counts and cardiac function. Reduce idarubicin dose if excess toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Idarubicin with Sotorasib?
MediHelp rates the interaction as moderate. Idarubicin and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib has been shown to inhibit P-glycoprotein, so higher idarubicin exposure is plausible rather than lower. The clinical consequence is poorly characterised and could include more myelosuppression or cardiotoxicity.
How serious is the interaction between Idarubicin and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function. Reduce idarubicin dose if excess toxicity develops.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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