Drug interactions
Ifosfamide + Indinavir
Severity: Moderate
Ifosfamide and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a potent CYP3A4 inhibitor and may reduce the activation of ifosfamide, potentially lowering antitumor effect. It may also shift metabolism away from the neurotoxic chloroacetaldehyde pathway, so the net result is unpredictable.
What this interaction means in plain words
Ifosfamide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated ifosfamide metabolism by indinavir.
What to do
Monitor for treatment response and for neurotoxicity and nephrotoxicity; consider an alternative antiretroviral without strong CYP3A4 inhibition if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ifosfamide and Indinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Indinavir?
MediHelp rates the interaction as moderate. Ifosfamide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a potent CYP3A4 inhibitor and may reduce the activation of ifosfamide, potentially lowering antitumor effect. It may also shift metabolism away from the neurotoxic chloroacetaldehyde pathway, so the net result is unpredictable.
How serious is the interaction between Ifosfamide and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for treatment response and for neurotoxicity and nephrotoxicity; consider an alternative antiretroviral without strong CYP3A4 inhibition if feasible.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
