Drug interactions
Ifosfamide + Influenza virus vaccine quadrivalent adjuvanted
Severity: Moderate
Ifosfamide and Influenza virus vaccine quadrivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide can blunt antibody responses to inactivated influenza vaccine, so protection may be lower. The vaccine remains safe and is still recommended in patients receiving chemotherapy.
What this interaction means in plain words
Ifosfamide and Influenza virus vaccine quadrivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced myelosuppression and lymphopenia reduce the humoral response to vaccination.
What to do
Do not withhold the inactivated vaccine; where feasible give it between chemotherapy cycles when counts are recovering. Consider vaccinating close contacts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Influenza virus vaccine quadrivalent adjuvanted?
MediHelp rates the interaction as moderate. Ifosfamide and Influenza virus vaccine quadrivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide can blunt antibody responses to inactivated influenza vaccine, so protection may be lower. The vaccine remains safe and is still recommended in patients receiving chemotherapy.
How serious is the interaction between Ifosfamide and Influenza virus vaccine quadrivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not withhold the inactivated vaccine; where feasible give it between chemotherapy cycles when counts are recovering. Consider vaccinating close contacts.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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