Drug interactions
Ifosfamide + Influenza virus vaccine quadrivalent
Severity: Moderate
Ifosfamide and Influenza virus vaccine quadrivalent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide causes myelosuppression and lymphopenia, which can blunt the antibody response to an inactivated influenza vaccine. Protection may be incomplete, but the vaccine cannot cause infection, so the combination is not contraindicated.
What this interaction means in plain words
Ifosfamide and Influenza virus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocyte function reduces the immune response to the vaccine antigen.
What to do
Vaccinate annually anyway, ideally before chemotherapy starts or between cycles when counts have recovered. Do not rely on the response alone and apply other infection-prevention measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Influenza virus vaccine quadrivalent?
MediHelp rates the interaction as moderate. Ifosfamide and Influenza virus vaccine quadrivalent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide causes myelosuppression and lymphopenia, which can blunt the antibody response to an inactivated influenza vaccine. Protection may be incomplete, but the vaccine cannot cause infection, so the combination is not contraindicated.
How serious is the interaction between Ifosfamide and Influenza virus vaccine quadrivalent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate annually anyway, ideally before chemotherapy starts or between cycles when counts have recovered. Do not rely on the response alone and apply other infection-prevention measures.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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