Drug interactions
Ifosfamide + Interferon beta 1b
Severity: Moderate
Ifosfamide and Interferon beta 1b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can suppress bone marrow function, so combined use may increase the risk of leukopenia, anemia, thrombocytopenia and infection. Interferon beta also has hepatic effects that add to the burden of chemotherapy.
What this interaction means in plain words
Ifosfamide and Interferon beta 1b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Interferon beta 1b belongs to Central Nervous System.
Why it happens
Additive myelosuppression through pharmacodynamic synergy.
What to do
Monitor complete blood counts regularly and adjust or delay ifosfamide or interferon dosing for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Interferon beta 1b
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Interferon beta 1b?
MediHelp rates the interaction as moderate. Ifosfamide and Interferon beta 1b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can suppress bone marrow function, so combined use may increase the risk of leukopenia, anemia, thrombocytopenia and infection. Interferon beta also has hepatic effects that add to the burden of chemotherapy.
How serious is the interaction between Ifosfamide and Interferon beta 1b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust or delay ifosfamide or interferon dosing for significant cytopenias.
What other medicines interact with Interferon beta 1b?
MediHelp also lists interactions of Interferon beta 1b with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Ciltacabtagene autoleucel. The full list is on the Interferon beta 1b page.
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