Drug interactions
Ifosfamide + Lumacaftor / ivacaftor
Severity: Moderate
Ifosfamide and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may increase ifosfamide bioactivation and formation of neurotoxic and nephrotoxic chloroacetaldehyde. This could raise the risk of CNS and renal toxicity.
What this interaction means in plain words
Ifosfamide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and possibly CYP2B6 by lumacaftor increases ifosfamide metabolism.
What to do
Monitor closely for encephalopathy, renal function and myelosuppression, and consider ifosfamide dose review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Ifosfamide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may increase ifosfamide bioactivation and formation of neurotoxic and nephrotoxic chloroacetaldehyde. This could raise the risk of CNS and renal toxicity.
How serious is the interaction between Ifosfamide and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for encephalopathy, renal function and myelosuppression, and consider ifosfamide dose review.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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