Drug interactions
Ifosfamide + Meningococcal a c y and w-135 polysaccharide vaccine combined
Severity: Moderate
Ifosfamide and Meningococcal a c y and w-135 polysaccharide vaccine combined: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with ifosfamide may lower the antibody response to the meningococcal polysaccharide vaccine. Protection against invasive disease may be inadequate.
What this interaction means in plain words
Ifosfamide and Meningococcal a c y and w-135 polysaccharide vaccine combined can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccination.
What to do
Vaccinate at least 2 weeks before chemotherapy when feasible. Revaccinate about 3 months after therapy if given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Meningococcal a c y and w-135 polysaccharide vaccine combined?
MediHelp rates the interaction as moderate. Ifosfamide and Meningococcal a c y and w-135 polysaccharide vaccine combined can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy with ifosfamide may lower the antibody response to the meningococcal polysaccharide vaccine. Protection against invasive disease may be inadequate.
How serious is the interaction between Ifosfamide and Meningococcal a c y and w-135 polysaccharide vaccine combined?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy when feasible. Revaccinate about 3 months after therapy if given during treatment.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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