Drug interactions
Ifosfamide + Metronidazole
Severity: Minor
Ifosfamide and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide requires hepatic activation by CYP enzymes, and its metabolism can shift if CYP3A4 activity is altered. Metronidazole is at most a weak CYP3A4 inhibitor, so a clinically meaningful loss of efficacy or change in neurotoxicity is not well documented.
What this interaction means in plain words
Ifosfamide and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ifosfamide belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
Theoretical weak CYP3A4 inhibition by metronidazole could reduce activation of ifosfamide; clinical relevance is unproven.
What to do
No routine dose change is needed; watch for reduced response and for ifosfamide-related encephalopathy, since metronidazole itself can cause neurotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Metronidazole?
MediHelp rates the interaction as minor. Ifosfamide and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ifosfamide requires hepatic activation by CYP enzymes, and its metabolism can shift if CYP3A4 activity is altered. Metronidazole is at most a weak CYP3A4 inhibitor, so a clinically meaningful loss of efficacy or change in neurotoxicity is not well documented.
How serious is the interaction between Ifosfamide and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for reduced response and for ifosfamide-related encephalopathy, since metronidazole itself can cause neurotoxicity.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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