Drug interactions
Ifosfamide + Nafcillin
Severity: Moderate
Ifosfamide and Nafcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may increase ifosfamide metabolism and formation of chloroacetaldehyde. This could increase neurotoxicity and nephrotoxicity.
What this interaction means in plain words
Ifosfamide and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by nafcillin increases ifosfamide metabolism.
What to do
Monitor for CNS and renal toxicity during co-administration, and consider an alternative antibiotic if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Nafcillin?
MediHelp rates the interaction as moderate. Ifosfamide and Nafcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nafcillin is a CYP3A4 inducer and may increase ifosfamide metabolism and formation of chloroacetaldehyde. This could increase neurotoxicity and nephrotoxicity.
How serious is the interaction between Ifosfamide and Nafcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS and renal toxicity during co-administration, and consider an alternative antibiotic if toxicity emerges.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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