Drug interactions
Ifosfamide + Olaparib
Severity: Moderate
Ifosfamide and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause bone marrow suppression, and the combination can increase anemia, neutropenia and thrombocytopenia. Prolonged cytopenias may require dose reductions or delays.
What this interaction means in plain words
Ifosfamide and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from a DNA-damaging alkylator and a PARP inhibitor.
What to do
Monitor complete blood counts frequently and reduce doses or interrupt treatment for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Ifosfamide with Olaparib?
MediHelp rates the interaction as moderate. Ifosfamide and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause bone marrow suppression, and the combination can increase anemia, neutropenia and thrombocytopenia. Prolonged cytopenias may require dose reductions or delays.
How serious is the interaction between Ifosfamide and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or interrupt treatment for significant cytopenias.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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