Drug interactions
Ifosfamide + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Ifosfamide and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a prodrug that is activated mainly by CYP3A4 and CYP2B6. The ritonavir-boosted regimen strongly inhibits CYP3A4, which may reduce formation of active alkylating metabolites and shift metabolism away from the activation pathway. The clinical consequence is uncertain, but it could include reduced antitumour activity.
What this interaction means in plain words
Ifosfamide and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition by ritonavir and paritaprevir alters ifosfamide bioactivation and may reduce exposure to active metabolites.
What to do
Where possible, avoid strong CYP3A4 inhibitors during ifosfamide courses or time the antiviral regimen away from chemotherapy. If they must be combined, monitor for reduced response and for unexpected toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Ifosfamide and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is a prodrug that is activated mainly by CYP3A4 and CYP2B6. The ritonavir-boosted regimen strongly inhibits CYP3A4, which may reduce formation of active alkylating metabolites and shift metabolism away from the activation pathway. The clinical consequence is uncertain, but it could include reduced antitumour activity.
How serious is the interaction between Ifosfamide and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, avoid strong CYP3A4 inhibitors during ifosfamide courses or time the antiviral regimen away from chemotherapy. If they must be combined, monitor for reduced response and for unexpected toxicity.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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