Drug interactions
Ifosfamide + Pegfilgrastim
Severity: Moderate
Ifosfamide and Pegfilgrastim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegfilgrastim sensitizes rapidly dividing myeloid precursors to cytotoxic drugs, so giving it around the time of ifosfamide may increase marrow toxicity and reduce its benefit. Its long-acting nature makes timing important.
What this interaction means in plain words
Ifosfamide and Pegfilgrastim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Pegfilgrastim belongs to Miscellaneous.
Why it happens
Growth factor-induced proliferation of myeloid progenitors increases their susceptibility to cytotoxic chemotherapy.
What to do
Give pegfilgrastim no sooner than 24 hours after completing ifosfamide, and not within 14 days before the next chemotherapy cycle. Monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ifosfamide and Pegfilgrastim, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Pegfilgrastim?
MediHelp rates the interaction as moderate. Ifosfamide and Pegfilgrastim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegfilgrastim sensitizes rapidly dividing myeloid precursors to cytotoxic drugs, so giving it around the time of ifosfamide may increase marrow toxicity and reduce its benefit. Its long-acting nature makes timing important.
How serious is the interaction between Ifosfamide and Pegfilgrastim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pegfilgrastim no sooner than 24 hours after completing ifosfamide, and not within 14 days before the next chemotherapy cycle. Monitor blood counts.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
