Drug interactions
Ifosfamide + Peramivir
Severity: Moderate
Ifosfamide and Peramivir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is cleared almost entirely by the kidneys, and ifosfamide can impair renal function. If kidney function deteriorates, peramivir exposure can rise. The effect is theoretical and depends on the degree of renal injury.
What this interaction means in plain words
Ifosfamide and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ifosfamide-induced nephrotoxicity may reduce renal elimination of peramivir.
What to do
Check renal function before dosing and adjust peramivir by creatinine clearance. Reassess if kidney function changes during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Peramivir?
MediHelp rates the interaction as moderate. Ifosfamide and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peramivir is cleared almost entirely by the kidneys, and ifosfamide can impair renal function. If kidney function deteriorates, peramivir exposure can rise. The effect is theoretical and depends on the degree of renal injury.
How serious is the interaction between Ifosfamide and Peramivir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before dosing and adjust peramivir by creatinine clearance. Reassess if kidney function changes during treatment.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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