Drug interactions
Ifosfamide + Poliovirus vaccine inactivated
Severity: Moderate
Ifosfamide and Poliovirus vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide causes myelosuppression and lymphopenia, which can blunt the antibody response to inactivated poliovirus vaccine. The vaccine cannot cause infection, but the patient may be left without adequate protection.
What this interaction means in plain words
Ifosfamide and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs B- and T-cell responses needed for vaccine immunogenicity.
What to do
Give the vaccine at least 2 weeks before starting ifosfamide whenever possible. If it was given during chemotherapy, revaccinate at least 3 months after treatment ends once immune recovery has occurred.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Poliovirus vaccine inactivated?
MediHelp rates the interaction as moderate. Ifosfamide and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide causes myelosuppression and lymphopenia, which can blunt the antibody response to inactivated poliovirus vaccine. The vaccine cannot cause infection, but the patient may be left without adequate protection.
How serious is the interaction between Ifosfamide and Poliovirus vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before starting ifosfamide whenever possible. If it was given during chemotherapy, revaccinate at least 3 months after treatment ends once immune recovery has occurred.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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