Drug interactions
Ifosfamide + Rifampin
Severity: Moderate
Ifosfamide and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin strongly induces CYP3A4 and also CYP2B6, which can increase ifosfamide activation and chloroacetaldehyde formation. This may increase myelosuppression, neurotoxicity and nephrotoxicity. Changes in efficacy are less predictable.
What this interaction means in plain words
Ifosfamide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 and CYP2B6 increases ifosfamide metabolism to active and toxic metabolites.
What to do
Avoid rifampin during ifosfamide therapy when alternatives exist. If unavoidable, monitor for encephalopathy, renal toxicity and cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Rifampin?
MediHelp rates the interaction as moderate. Ifosfamide and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin strongly induces CYP3A4 and also CYP2B6, which can increase ifosfamide activation and chloroacetaldehyde formation. This may increase myelosuppression, neurotoxicity and nephrotoxicity. Changes in efficacy are less predictable.
How serious is the interaction between Ifosfamide and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rifampin during ifosfamide therapy when alternatives exist. If unavoidable, monitor for encephalopathy, renal toxicity and cytopenias.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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