Drug interactions
Ifosfamide + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Ifosfamide and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral sulfate bowel preparations can cause fluid loss and electrolyte disturbance. Ifosfamide may cause renal tubular injury and electrolyte wasting, and dehydration or electrolyte shifts may worsen kidney injury or arrhythmia risk.
What this interaction means in plain words
Ifosfamide and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive fluid and electrolyte disturbance with a risk of worsened renal injury.
What to do
Ensure adequate hydration and check electrolytes and renal function before and after bowel preparation. Correct abnormalities before ifosfamide administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Ifosfamide and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral sulfate bowel preparations can cause fluid loss and electrolyte disturbance. Ifosfamide may cause renal tubular injury and electrolyte wasting, and dehydration or electrolyte shifts may worsen kidney injury or arrhythmia risk.
How serious is the interaction between Ifosfamide and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check electrolytes and renal function before and after bowel preparation. Correct abnormalities before ifosfamide administration.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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