Drug interactions
Ifosfamide + Streptozocin
Severity: Major
Ifosfamide and Streptozocin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and both can cause myelosuppression. Combining them increases the risk of renal tubular damage and cytopenias, and streptozocin nephrotoxicity is often dose-limiting.
What this interaction means in plain words
Ifosfamide and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity and bone marrow suppression.
What to do
Avoid concurrent use where possible. If combined, monitor renal function, electrolytes and blood counts closely, ensure hydration, and reduce doses as renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Streptozocin?
MediHelp rates the interaction as major. Ifosfamide and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and both can cause myelosuppression. Combining them increases the risk of renal tubular damage and cytopenias, and streptozocin nephrotoxicity is often dose-limiting.
How serious is the interaction between Ifosfamide and Streptozocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If combined, monitor renal function, electrolytes and blood counts closely, ensure hydration, and reduce doses as renal function declines.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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