Drug interactions
Ifosfamide + Talimogene laherparepvec
Severity: Contraindicated
Ifosfamide and Talimogene laherparepvec: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talimogene laherparepvec is a live, modified herpes simplex virus that replicates in tissue. In patients immunosuppressed by ifosfamide, this could lead to disseminated or serious herpetic infection.
What this interaction means in plain words
Ifosfamide and Talimogene laherparepvec are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ifosfamide belongs to Oncology; Talimogene laherparepvec belongs to Oncology.
Why it happens
Immunosuppression from chemotherapy impairs control of the replicating oncolytic herpes virus.
What to do
Do not give talimogene laherparepvec to patients receiving ifosfamide or otherwise immunocompromised. Choose an alternative therapy and consult the oncology team.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Talimogene laherparepvec
Frequently asked questions
Can I take Ifosfamide with Talimogene laherparepvec?
MediHelp rates the interaction as contraindicated. Ifosfamide and Talimogene laherparepvec are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Talimogene laherparepvec is a live, modified herpes simplex virus that replicates in tissue. In patients immunosuppressed by ifosfamide, this could lead to disseminated or serious herpetic infection.
How serious is the interaction between Ifosfamide and Talimogene laherparepvec?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give talimogene laherparepvec to patients receiving ifosfamide or otherwise immunocompromised. Choose an alternative therapy and consult the oncology team.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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