Drug interactions
Ifosfamide + Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine
Severity: Moderate
Ifosfamide and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide-induced immunosuppression can weaken the antibody response to Tdap vaccination. Protection against tetanus, diphtheria and pertussis may be lower than expected.
What this interaction means in plain words
Ifosfamide and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs the immune response to vaccine antigens.
What to do
Vaccinate at least 2 weeks before starting chemotherapy when possible. If given during therapy, revaccinate at least 3 months after treatment ends once immune function has recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates the interaction as moderate. Ifosfamide and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide-induced immunosuppression can weaken the antibody response to Tdap vaccination. Protection against tetanus, diphtheria and pertussis may be lower than expected.
How serious is the interaction between Ifosfamide and Tetanus and reduced diphtheria toxoids / acellular pertussis vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before starting chemotherapy when possible. If given during therapy, revaccinate at least 3 months after treatment ends once immune function has recovered.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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