Drug interactions
Ifosfamide + Thiotepa
Severity: Major
Ifosfamide and Thiotepa: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are alkylating drugs that cause myelosuppression. Thiotepa is also metabolised by CYP3A4 and CYP2B6, so the two drugs may compete for metabolism and alter exposure to active metabolites. Overlapping toxicities include profound cytopenias and neurotoxicity.
What this interaction means in plain words
Ifosfamide and Thiotepa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ifosfamide belongs to Oncology; Thiotepa belongs to Oncology.
Why it happens
Additive myelosuppression and organ toxicity, with possible competition for CYP2B6/3A4 metabolism.
What to do
Monitor blood counts and neurological and renal status closely, and follow protocol dose reductions in high-dose regimens. Provide supportive care for cytopenias.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Thiotepa
- Bendamustine + Thiotepa Major
- Chlorambucil + Thiotepa Major
- Clarithromycin + Thiotepa Major
- Cyclophosphamide + Thiotepa Major
- Dacarbazine + Thiotepa Major
- Deferiprone + Thiotepa Major
Frequently asked questions
Can I take Ifosfamide with Thiotepa?
MediHelp rates the interaction as major. Ifosfamide and Thiotepa can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are alkylating drugs that cause myelosuppression. Thiotepa is also metabolised by CYP3A4 and CYP2B6, so the two drugs may compete for metabolism and alter exposure to active metabolites. Overlapping toxicities include profound cytopenias and neurotoxicity.
How serious is the interaction between Ifosfamide and Thiotepa?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurological and renal status closely, and follow protocol dose reductions in high-dose regimens. Provide supportive care for cytopenias.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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