Drug interactions
Iloprost inhaled + Lofexidine
Severity: Moderate
Iloprost inhaled and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a prostacyclin vasodilator and lofexidine lowers blood pressure and heart rate. Inhaled iloprost has some systemic absorption, so additive hypotension may occur.
What this interaction means in plain words
Iloprost inhaled and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from prostacyclin-mediated vasodilation and central alpha-2 sympatholysis.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Iloprost inhaled with Lofexidine?
MediHelp rates the interaction as moderate. Iloprost inhaled and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a prostacyclin vasodilator and lofexidine lowers blood pressure and heart rate. Inhaled iloprost has some systemic absorption, so additive hypotension may occur.
How serious is the interaction between Iloprost inhaled and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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