Drug interactions
Imipramine + Indacaterol inhaled
Severity: Moderate
Imipramine and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists. Indacaterol can cause tachycardia, hypokalemia and QTc prolongation, so combined use raises the risk of arrhythmia.
What this interaction means in plain words
Imipramine and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and enhanced adrenergic cardiovascular effects.
What to do
Monitor heart rate, ECG and serum potassium, especially in patients with cardiac disease or other QT-prolonging drugs. Reassess if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Imipramine and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta-2 agonists. Indacaterol can cause tachycardia, hypokalemia and QTc prolongation, so combined use raises the risk of arrhythmia.
How serious is the interaction between Imipramine and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and serum potassium, especially in patients with cardiac disease or other QT-prolonging drugs. Reassess if palpitations or syncope occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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