Drug interactions
Imipramine + Indinavir
Severity: Moderate
Imipramine and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, which contributes to imipramine demethylation, and may raise imipramine concentrations. Higher levels increase the risk of anticholinergic effects, sedation, hypotension and cardiac conduction abnormalities.
What this interaction means in plain words
Imipramine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated imipramine metabolism by indinavir.
What to do
Monitor for tricyclic toxicity and consider checking imipramine levels or ECG; reduce the imipramine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Indinavir?
MediHelp rates the interaction as moderate. Imipramine and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4, which contributes to imipramine demethylation, and may raise imipramine concentrations. Higher levels increase the risk of anticholinergic effects, sedation, hypotension and cardiac conduction abnormalities.
How serious is the interaction between Imipramine and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider checking imipramine levels or ECG; reduce the imipramine dose if adverse effects occur.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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