Drug interactions
Imipramine + Insulin lispro
Severity: Minor
Imipramine and Insulin lispro: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may alter glycemic control and potentiate the glucose-lowering effect of insulin. Hypoglycemia may occur unexpectedly and its adrenergic warning symptoms may be blunted.
What this interaction means in plain words
Imipramine and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Insulin lispro belongs to Endocrine.
Why it happens
Tricyclics may alter insulin sensitivity and glucose homeostasis, an additive pharmacodynamic effect that is not fully characterized.
What to do
Monitor blood glucose more often when imipramine is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Insulin lispro
Frequently asked questions
Can I take Imipramine with Insulin lispro?
MediHelp rates the interaction as minor. Imipramine and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may alter glycemic control and potentiate the glucose-lowering effect of insulin. Hypoglycemia may occur unexpectedly and its adrenergic warning symptoms may be blunted.
How serious is the interaction between Imipramine and Insulin lispro?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when imipramine is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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