Drug interactions
Imipramine + Insulin nph
Severity: Minor
Imipramine and Insulin nph: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. They can also blunt or mask some adrenergic warning symptoms. The effect is usually small.
What this interaction means in plain words
Imipramine and Insulin nph have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive effect on glucose lowering, possibly through altered insulin sensitivity or glucose handling; mechanism not fully established.
What to do
Monitor blood glucose more frequently when imipramine is started, changed or stopped, and adjust insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Insulin nph?
MediHelp rates the interaction as minor. Imipramine and Insulin nph have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. They can also blunt or mask some adrenergic warning symptoms. The effect is usually small.
How serious is the interaction between Imipramine and Insulin nph?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when imipramine is started, changed or stopped, and adjust insulin dose if hypoglycemia occurs.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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