Drug interactions
Imipramine + Ketamine
Severity: Moderate
Imipramine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine produces sedation and sympathomimetic effects such as tachycardia and hypertension, while imipramine adds CNS depression and may heighten cardiovascular responses. The combination may deepen sedation and increase blood pressure or arrhythmia risk.
What this interaction means in plain words
Imipramine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive sympathomimetic cardiovascular effects.
What to do
Monitor blood pressure, heart rate and level of sedation during and after ketamine administration. Use lower ketamine doses in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Imipramine with Ketamine?
MediHelp rates the interaction as moderate. Imipramine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine produces sedation and sympathomimetic effects such as tachycardia and hypertension, while imipramine adds CNS depression and may heighten cardiovascular responses. The combination may deepen sedation and increase blood pressure or arrhythmia risk.
How serious is the interaction between Imipramine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and level of sedation during and after ketamine administration. Use lower ketamine doses in patients with cardiovascular disease.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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